rs11190870 is not associated with severity of adolescent idiopathic scoliosis in Japanese
نویسندگان
چکیده
Objective We previously conducted a genome-wide association study for AIS susceptibility in Japanese and identified a SNP, rs11190870 near the LBX1 gene on chromosome 10q24.1 that showed significant association. The association is replicated in other populations of different ethnicities. However, it is controversial whether rs11190870 is also associated with severity of the scoliosis curve in AIS. To examine whether rs11190870 is associated with curve severity of AIS in Japanese, we investigated the association using 2,191 (2,068 female and 123 male) subjects.
منابع مشابه
Association between Common Variants near LBX1 and Adolescent Idiopathic Scoliosis Replicated in the Chinese Han Population
BACKGROUND Adolescent idiopathic scoliosis (AIS) is one of the most common spinal deformities found in adolescent populations. Recently, a genome-wide association study (GWAS) in a Japanese population indicated that three single nucleotide polymorphisms (SNPs), rs11190870, rs625039 and rs11598564, all located near the LBX1 gene, may be associated with AIS susceptibility [1]. This study suggests...
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